Lipotoxicity and β Cell Maintenance in Obesity and Type 2 Diabetes
نویسندگان
چکیده
منابع مشابه
Lack of Lipotoxicity Effect on β-Cell Dysfunction in Ketosis-Prone Type 2 Diabetes
OBJECTIVE Over half of newly diagnosed obese African Americans with diabetic ketoacidosis (DKA) discontinue insulin therapy and go through a period of near-normoglycemia remission. This subtype of diabetes is known as ketosis-prone type 2 diabetes (KPDM). RESEARCH DESIGN AND METHODS To investigate the role of lipotoxicity on beta-cell function, eight obese African Americans with KPDM, eight obe...
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Abstract Objective: Adiponectin and vaspin are adipocyte-derived proteins and involved in the regulation of glucose metabolism and obesity related disorders. The mechanisms that adipokines might be linked to disturbance of glucose are unclear. Thus, this study investigated the levels of serum adiponectin and vaspin, blood lipid profiles, and abdominal obesity in type 2 diabetes (T2DM) patients...
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Type 2 diabetic patients are insulin resistant as a result of obesity and a sedentary lifestyle. Nevertheless, it has been known for the past five decades that insulin response to nutrients is markedly diminished in type 2 diabetes. There is now a consensus that impaired glucose regulation cannot develop without insulin deficiency. First-phase insulin response to glucose is lost very early in t...
متن کاملObesity and type 2 diabetes
Obesity and type 2 diabetes (T2DM) are public health problems, with health consequences and economic costs that have raised concern worldwide. The increase in the prevalence of diabetes parallels that of obesity. Some experts call this dual epidemic “diabesity”. Elevated body mass index (BMI) and waist circumference (WC) were significantly associated T2DM. One consequence of obesity is an incre...
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ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2019
ISSN: 2472-1972
DOI: 10.1210/js.2018-00372